Data-driven Approach Research Articles

Data-driven economic MPC with asymptotic stability and strong duality verification using Hankel matrix

We consider the problem of dynamic regulation with an economic cost function to control unknown linear systems, in which improving the economic performance and guaranteeing the stability of economical optimal equilibrium point are control objectives. A data-driven economic MPC scheme is presented using measured input-output trajectories without a prior system identification step. Our method uses Hankel matrices which include one input-output data trajectory for prediction in economic MPC, while persistently exciting of the input generating the data is needed. One of the novelties of the presented framework is directly verifying the strong duality property from input-output trajectory with the general cost function, considered as the supply rate. This is used to find a Lyapunov function for data-driven economic MPC. Under the strong duality assumption, asymptotic stability of the economical optimal equilibrium point for the closed-loop system with terminal equality constraint is guaranteed. The proposed data-driven economic MPC approach needs only persistently exciting data trajectory along with an upper bound on the system order and need no model description and no online parameter estimation. The proposed scheme applicability compared to the existing model-based economic MPC and data-driven MPC is illustrated for continuous stirred tank reactor (CSTR) and a numerical example and the robustness of the proposed scheme is evaluated in the case of measurement noise, as well as nonlinear model for CSTR system.

A Psychometric Network Analysis Approach for Detecting Item Wording Effects in Self-report Measures across Subgroups

In this study, we explored psychometric network analysis (PNA) as an alternative method for identifying item wording effects in self-report instruments. We examined the functioning of negatively worded items in the network structures of two math-related scales from the 2019 Trends in International Mathematics and Science Study (TIMSS); Students Like Learning in Mathematics (SLLM); and Students Confident in Mathematics (SCM). We also explored how the negatively worded items functioned in network structures across demographic subgroups. Data were drawn from eight countries that represented diverse levels of math performance and cultural attitudes toward school ( n = 75,972). We found that negatively worded items were distinct from the positively worded items in the SLLM and SCM item networks, and that this effect was consistent across all age- and country-level subgroups. Based on these findings, we recommend PNA as a data-driven approach for detecting wording effects effectively.

Deformable motion compensation in interventional cone-beam CT with a context-aware learned autofocus metric.

Interventional Cone-Beam CT (CBCT) offers 3D visualization of soft-tissue and vascular anatomy, enabling 3D guidance of abdominal interventions. However, its long acquisition time makes CBCT susceptible to patient motion. Image-based autofocus offers a suitable platform for compensation of deformable motion in CBCT, but it relies on handcrafted motion metrics based on first-order image properties and that lack awareness of the underlying anatomy. This work proposes a data-driven approach to motion quantification via a learned, context-aware, deformable metric, , that quantifies the amount of motion degradation as well as the realism of the structural anatomical content in the image. The proposed was modeled as a deep convolutional neural network (CNN) trained to recreate a reference-based structural similarity metric-visual information fidelity (VIF). The deep CNN acted on motion-corrupted images, providing an estimation of the spatial VIF map that would be obtained against a motion-free reference, capturing motion distortion, and anatomic plausibility. The deep CNN featured a multi-branch architecture with a high-resolution branch for estimation of voxel-wise VIF on a small volume of interest. A second contextual, low-resolution branch provided features associated to anatomical context for disentanglement of motion effects and anatomical appearance. The deep CNN was trained on paired motion-free and motion-corrupted data obtained with a high-fidelity forward projection model for a protocol involving 120kV and 9.90mGy. The performance of was evaluated via metrics of correlation with ground truth and with the underlying deformable motion field in simulated data with deformable motion fields with amplitude ranging from 5 to 20mm and frequency from 2.4 up to 4 cycles/scan. Robustness to variation in tissue contrast and noise levels was assessed in simulation studies with varying beam energy (90-120kV) and dose (1.19-39.59mGy). Further validation was obtained on experimental studies with a deformable phantom. Final validation was obtained via integration of on an autofocus compensation framework, applied to motion compensation on experimental datasets and evaluated via metric of spatial resolution on soft-tissue boundaries and sharpness of contrast-enhanced vascularity. The magnitude and spatial map of showed consistent and high correlation levels with the ground truth in both simulation and real data, yielding average normalized cross correlation (NCC) values of 0.95 and 0.88, respectively. Similarly, achieved good correlation values with the underlying motion field, with average NCC of 0.90. In experimental phantom studies, properly reflects the change in motion amplitudes and frequencies: voxel-wise averaging of the local across the full reconstructed volume yielded an average value of 0.69 for the case with mild motion (2mm, 12 cycles/scan) and 0.29 for the case with severe motion (12mm, 6 cycles/scan). Autofocus motion compensation using resulted in noticeable mitigation of motion artifacts and improved spatial resolution of soft tissue and high-contrast structures, resulting in reduction of edge spread function width of 8.78% and 9.20%, respectively. Motion compensation also increased the conspicuity of contrast-enhanced vascularity, reflected in an increase of 9.64% in vessel sharpness. The proposed , featuring a novel context-aware architecture, demonstrated its capacity as a reference-free surrogate of structural similarity to quantify motion-induced degradation of image quality and anatomical plausibility of image content. The validation studies showed robust performance across motion patterns, x-ray techniques, and anatomical instances. The proposed anatomy- and context-aware metric poses a powerful alternative to conventional motion estimation metrics, and a step forward for application of deep autofocus motion compensation for guidance in clinical interventional procedures.

A Data-Driven Approach to Defining Risk-Adjusted Coding Specificity Metrics for a Large U.S. Dementia Patient Cohort

Medical coding impacts patient care quality, payor reimbursement, and system reliability through the precision of patient information documentation. Inadequate coding specificity can have significant consequences at administrative and patient levels. Models to identify and/or enhance coding specificity practices are needed. Clinical records are not always available, complete, or homogeneous, and clinically driven metrics to assess medical practices are not logistically feasible at the population level, particularly in non-centralized healthcare delivery systems and/or for those who only have access to claims data. Data-driven approaches that incorporate all available information are needed to explore coding specificity practices. Using N = 487,775 hospitalization records of individuals diagnosed with dementia and discharged in 2022 from a large all-payor administrative claims dataset, we fitted logistic regression models using patient and facility characteristics to explain the coding specificity of principal and secondary diagnoses of dementia. A two-step approach was produced to allow for the flexible clustering of patient-level outcomes. Model outcomes were then used within a Poisson binomial model to identify facilities that over- or under-specify dementia diagnoses against healthcare industry standards across hospitalizations. The results indicate that multiple factors are significantly associated with dementia coding specificity, especially for principal diagnoses of dementia (AUC = 0.727). The practical use of this novel risk-adjusted metric is demonstrated for a sample of facilities and geospatially via a U.S. map. This study’s findings provide healthcare facilities with a benchmark for assessing coding specificity practices and developing quality enhancements to align with healthcare industry standards, ultimately contributing to better patient care and healthcare system reliability.

EyeXNet: Enhancing Abnormality Detection and Diagnosis via Eye-Tracking and X-ray Fusion

Integrating eye gaze data with chest X-ray images in deep learning (DL) has led to contradictory conclusions in the literature. Some authors assert that eye gaze data can enhance prediction accuracy, while others consider eye tracking irrelevant for predictive tasks. We argue that this disagreement lies in how researchers process eye-tracking data as most remain agnostic to the human component and apply the data directly to DL models without proper preprocessing. We present EyeXNet, a multimodal DL architecture that combines images and radiologists’ fixation masks to predict abnormality locations in chest X-rays. We focus on fixation maps during reporting moments as radiologists are more likely to focus on regions with abnormalities and provide more targeted regions to the predictive models. Our analysis compares radiologist fixations in both silent and reporting moments, revealing that more targeted and focused fixations occur during reporting. Our results show that integrating the fixation masks in a multimodal DL architecture outperformed the baseline model in five out of eight experiments regarding average Recall and six out of eight regarding average Precision. Incorporating fixation masks representing radiologists’ classification patterns in a multimodal DL architecture benefits lesion detection in chest X-ray (CXR) images, particularly when there is a strong correlation between fixation masks and generated proposal regions. This highlights the potential of leveraging fixation masks to enhance multimodal DL architectures for CXR image analysis. This work represents a first step towards human-centered DL, moving away from traditional data-driven and human-agnostic approaches.

Automated W7-X sawtooth crashes detection and characterisation

Abstract Sawtooth crashes are observed during ECCD experiments at the superconducting optimized stellarator Wendelstein 7-X. The study and the characterization are necessary in order to understand under which condition ECCD can be driven without posing a risk to experimental operations. The development of automatic tools is crucial to speed up the analysis and use extensive datasets. In this work we report on the first attempt of using a data-driven approach to automatically characterise the sawtooth crashes. Cluster algorithms are applied to the dataset, confirming the existence of two distinct types of crashes. This approach allows to study the two groups separately and underlines the different plasma parameters that influence the sawtooth crash parameters, for instance crash amplitude and period.

High-Resolution Estimates of N2O Emissions from Inland Waters and Wetlands in China.

Inland waters (rivers, lakes, and reservoirs) and wetlands (marshes and coastal wetlands) represent large and continuous sources of nitrous oxide (N2O) emissions, in view of adequate biomass and anaerobic conditions. Considerable uncertainties remain in quantifying spatially explicit N2O emissions from aquatic systems, attributable to the limitations of models and a lack of comprehensive data sets. Herein, we conducted a synthesis of 1659 observations of N2O emission rates to determine the major environmental drivers across five aquatic systems. A framework for spatially explicit estimates of N2O emissions in China was established, employing a data-driven approach that upscaled from site-specific N2O fluxes to robust multiple-regression models. Results revealed the effectiveness of models incorporating soil organic carbon and water content for marshes and coastal wetlands, as well as water nitrate concentration and dissolved organic carbon for lakes, rivers, and reservoirs for predicting emissions. Total national N2O emissions from inland waters and wetlands were 1.02 × 105 t N2O yr-1, with contributions from marshes (36.33%), rivers (27.77%), lakes (25.27%), reservoirs (6.47%), and coastal wetlands (4.16%). Spatially, larger emissions occurred in the Songliao River Basin and Continental River Basin, primarily due to their substantial terrestrial biomass. This study offers a vital national inventory of N2O emissions from inland waters and wetlands in China, providing paradigms for the inventorying work in other countries and insights to formulate effective mitigation strategies for climate change.

Enhancing Mental Health Predictions: A Gradient Boosted Model for Sri Lankan Camp Refugees

This study explores the mental health challenges encountered by Sri Lankan camp refugees, a population often marginalized in mental health research, and analyzes a range of factors including socio-demographic characteristics, living conditions in camps, and psychological variables. In quantitative mental health research, linear regression serves as a conventional approach for assessing the influence of diverse factors on mental health outcomes. However, this method fails to accommodate non-linear relationships between mental health variables and predictors and relies on stringent model assumptions that often do not align with real-world conditions. This study introduces a model-agnostic, advanced machine learning/artificial intelligence (ML/AI) technique, glmboost, as a viable alternative to linear regression. The glmboost algorithm is capable of fitting non-linear prediction models while also conducting variable selection. Moreover, the coefficients obtained from the glmboost model retain the same interpretability as those derived from linear regression. While the glmboost model identifies several key factors including post-migration living difficulties, post-traumatic stress disorder, difficulty in sleeping, poor family functioning, and lower informal support from families as markers of declining mental well-being among the Sri Lankan refugees, the linear regression overlooks vital predictors such as family functioning and family support, highlighting the importance of utilizing advanced ML/AI techniques like glmboost to comprehensively capture complex relationships between predictor variables and mental health outcomes among refugee populations. Thus, by introducing a novel, data-driven approach to mental health risk assessment, this study paves the way for more precise and efficient analyses and interventions in refugee settings, with the potential for improved resource allocation and personalized support, thus revolutionizing mental health service delivery in challenging environments. Additionally, it contributes to the academic discussion on refugee mental health while emphasizing the pivotal role of advanced data analytics in addressing complex health issues within humanitarian contexts.

Performance prediction and operating parameters optimization for proton exchange membrane fuel cell based on data-driven surrogate model and particle swarm optimization

The operating parameters of proton exchange membrane fuel cell (PEMFC) are critical to its performance and working life. This study presents a data-driven modeling approach combining a surrogate model with the particle swarm optimization algorithm to optimize operating parameters for PEMFC and obtain the maximum power density. The results show that the operating parameters significantly influence power density under high current densities, with inlet temperature having the most significant effect. Lower inlet temperature, relative humidity in the cathode and anode, along with higher operating pressure yield improved output performance. The Genetic Algorithm-Backpropagation Neural Network based surrogate model exhibits excellent predictive performance with correlation coefficients of 0.99896 and 0.99815 for the training and test sets, respectively. Optimized conditions achieve a 3.3% increase in power density compared to initial settings, with only a 0.15% error in simulation calculations. This data-driven approach provides valuable insights for maximizing PEMFC efficiency and performance.

Medium-term forecasting of global horizontal solar radiation in Brazil using machine learning-based methods

The generation of electric energy through renewable sources, such as solar photovoltaic (PV) systems, has emerged as one solution to the climate change crisis. To avoid fluctuations in energy generation on the electricity grid, reliable and accurate forecasts are required. Statistical downscaling methodologies often rely on data from General Circulation Model (GCM) to provide information on the local level. In contrast to traditional downscaling approaches, the present study focuses on a data-driven approach using the Global Data Assimilation System (GDAS) database in three different ways to feed the machine learning (ML) models, based on boosting and bagging, to provide medium-term Global Horizontal Irradiance (GHI) forecasts, i.e. up to seven days ahead. In addition, feature selection and feature augmentation techniques are also applied. The results showed that Extra Trees method outperformed the other tested in the present study, with a RMSE of 99.6 and 137.6 W/m2, and correlation 0.31 and 0.52 for June and October, respectively. Thus far, this work marks the initial suggestion of incorporating GDAS analysis data into a data-driven forecasting approach employing bagging and boosting models. This innovative approach demonstrates the potential for integrating global-scale data assimilation systems with local measurements using ML techniques. The outcomes of this research contribute to advancing the field of traditional downscaling methods and provides more robust and specialized forecasting.

Assessing the Impact of Risk Factors on Vaccination Uptake Policy Decisions Using a Bayesian Network (BN) Approach

This study evaluates the propagation impact of three risk categories (hazard and exposure, socio-economic vulnerability, and lack of coping capacity) and their associated factors on vaccination uptake policy decisions in Pakistan. This study proposed Bayesian influence diagrams using expert elicitation and data-driven approaches. The Bayesian network (BN) approach uses the best policy algorithm to determine the expected utility of decisions. The study found that the government’s firm vaccine uptake decisions had a positive effect in Pakistan. The findings on hazard and exposure-related factors show that people living in rural areas were more susceptible to COVID-19 than people living in urban areas. Among socio-economic vulnerability factors, household characteristics were affected due to household economic situations, fear of using health facilities due to the spread of COVID-19, lack of public transportation services, food insecurity, a temporary halt in education, and weak governance, which affected the vaccination uptake decision. The factors linked with coping capacity show that the government’s financial assistance and development of digital platforms raised digital health literacy and increased vaccine uptake decision utility. The proposed methodology and results of this study can be used to develop contingency planning for any future potential pandemic situations.

Comprehensive energy demand and usage data for building automation

Buildings are essential in satisfying our daily need for comfort (privacy, protection from weather, etc.) and are responsible for almost half of the world’s total energy consumption. Research at the interface of room comfort and energy efficiency is of critical societal importance. At the same time, there is a lack of publicly available data to optimize important building functions automatically. It is only through data-driven approaches that building automation becomes financially affordable and achieves widespread adoption. In this publication, measurement data from three buildings of the NEST platform are made publicly available. The dataset includes detailed information on energy consumption (electricity, heating, cooling, domestic hot water), building operation (set points, valve openings, windows), and occupant practice (e.g., presence, operation of blinds and kitchen, showering patterns). All data have been measured over four years and with a temporal resolution of 1 minute. This combination of information allows learning the function of different building types (office and residential) and thus addresses important research gaps.

Data-driven approach for port resilience evaluation

As pivotal nodes in international trade, ports have faced unprecedented challenges, particularly in the context of the COVID-19 pandemic. From the perspective of port congestion, this study investigates port resilience based on a quantitative approach. Port resilience is specifically evaluated using five novel metrics derived from resilience capacities and port congestion indexes, employing data-driven approaches, which are then applied to analyze nine global ports across six regions. The findings of the study indicate that: 1) The ports of Southampton and Shanghai display better resilience levels, whereas New York/New Jersey and Los Angeles/Long Beach show poorer resilience performance during the research period. 2) Ports in West Coast North America demonstrate relatively low resilience levels, while those in South East Asia showcase superior resilience. 3) The changing dynamics and evolution of port resilience rankings across different years underscore the multifaceted nature of port resilience and its capacity to adapt to external factors such as global events. Our study emphasizes the importance of quantifying port resilience, with a specific focus on port congestion. It provides valuable insights that have significant implications for port management and disaster preparedness within the maritime industry.

Knowledge graph-guided data-driven design of ultra-high-performance concrete (UHPC) with interpretability and physicochemical reaction discovery capability

Traditional methods for designing concrete materials typically rely on labor-intensive laboratory experiments, resulting in time and cost inefficiencies. Recently, designing concrete using artificial intelligence (AI) methods has shown high efficiency, but existing AI methods often rely solely on data, which can lead to violation with scientific principles and result in models lacking reasoning abilities. To overcome these challenges, this paper presents an interpretable knowledge graph-guided data-driven design approach. By integrating advanced computing techniques with domain knowledge via knowledge graphs, this approach enables the interpretation of data-driven models and uncovers the underlying mechanisms behind predictions. This approach is applied to ultra-high-performance concrete (UHPC) involving complex physicochemical reactions. The domain knowledge about UHPC is imparted using a knowledge graph, and UHPC properties are predicted using a machine learning model considering mixing proportions, processing methods, and physiochemical properties of materials via natural language processing. The results show that the knowledge graph displays crucial design variables and their effects on UHPC properties, aiding in selecting variables for machine learning models and interpreting their results. The prediction accuracy of the machine learning model reached 0.95. The research paves the way for more transparent and scientific AI models for material design and AI-enabled discovery of scientific knowledge.

Exploring risky health behaviors and vulnerability to sexually transmitted diseases among transnational undocumented labor migrants from Bangladesh: a qualitative study

BackgroundIn Bangladesh, remittances constitute a substantial portion of the country’s foreign exchange earnings and serve as a primary source of income. However, a considerable number of Bangladeshi citizens reside overseas without proper documentation, exposing them to significant challenges such as limited access to healthcare and socioeconomic opportunities. Moreover, their irregular migration status often results in engaging in risky health behaviors that further exacerbate their vulnerability. Hence, this study aimed to investigate the risky health behavior and HIV/STI susceptibility of Bangladeshi irregular international migrants residing across the globe with undocumented status.MethodsUsing a qualitative Interpretative Phenomenological Approach (IPA), 25 illegal migrants were interviewed who are currently living illegally or returned to their home country. The author used a thematic approach to code and analyze the data, combining an integrated data-driven inductive approach with a deductive approach. Concurrent processing and coding were facilitated by employing the Granheim model in data analysis.ResultsThe study identified four risky health behaviors among irregular Bangladeshi migrants: hazardous living conditions, risky jobs, suicidal ideation, and tobacco consumption. Additionally, the authors found some HIV/STI risk behavior among them including engaging in unprotected sex, consuming alcohol and drugs during sexual activity, and having limited access to medical facilities.ConclusionsThe findings of this study can be used by health professional, governments, policymakers, NGOs, and concerned agencies to develop welfare strategies and initiatives for vulnerable undocumented migrant workers.

Uncertainty quantification in multivariable regression for material property prediction with Bayesian neural networks

With the increased use of data-driven approaches and machine learning-based methods in material science, the importance of reliable uncertainty quantification (UQ) of the predicted variables for informed decision-making cannot be overstated. UQ in material property prediction poses unique challenges, including multi-scale and multi-physics nature of materials, intricate interactions between numerous factors, limited availability of large curated datasets, etc. In this work, we introduce a physics-informed Bayesian Neural Networks (BNNs) approach for UQ, which integrates knowledge from governing laws in materials to guide the models toward physically consistent predictions. To evaluate the approach, we present case studies for predicting the creep rupture life of steel alloys. Experimental validation with three datasets of creep tests demonstrates that this method produces point predictions and uncertainty estimations that are competitive or exceed the performance of conventional UQ methods such as Gaussian Process Regression. Additionally, we evaluate the suitability of employing UQ in an active learning scenario and report competitive performance. The most promising framework for creep life prediction is BNNs based on Markov Chain Monte Carlo approximation of the posterior distribution of network parameters, as it provided more reliable results in comparison to BNNs based on variational inference approximation or related NNs with probabilistic outputs.

Controlling chaos using edge computing hardware

Machine learning provides a data-driven approach for creating a digital twin of a system – a digital model used to predict the system behavior. Having an accurate digital twin can drive many applications, such as controlling autonomous systems. Often, the size, weight, and power consumption of the digital twin or related controller must be minimized, ideally realized on embedded computing hardware that can operate without a cloud-computing connection. Here, we show that a nonlinear controller based on next-generation reservoir computing can tackle a difficult control problem: controlling a chaotic system to an arbitrary time-dependent state. The model is accurate, yet it is small enough to be evaluated on a field-programmable gate array typically found in embedded devices. Furthermore, the model only requires 25.0 ±7.0\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\pm 7.0$$\\end{document} nJ per evaluation, well below other algorithms, even without systematic power optimization. Our work represents the first step in deploying efficient machine learning algorithms to the computing “edge.”

ADHD classification with cross-dataset feature selection for biomarker consistency detection.

Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. While numerous intelligent methods are applied for its subjective diagnosis, they seldom consider the consistency problem of ADHD biomarkers. In practice, these data-driven approaches lead to varying learned features for ADHD classification across diverse ADHD datasets. This phenomenon significantly undermines the reliability of identified biomarkers and hampers the interpretability of these methods. In this study, we propose a cross-dataset feature selection (FS) module using a grouped SVM-based recursive feature elimination approach (G-SVM-RFE) to enhance biomarker consistency across multiple datasets. Additionally, we employ connectome gradient data for ADHD classification. Specifically, we introduce the G-SVM-RFE method to effectively concentrate gradient components within a limited number of brain regions, thereby increasing the likelihood of identifying these regions as ADHD biomarkers. The cross-dataset FS module is integrated into an existing binary hypothesis testing (BHT) framework. This module utilizes external datasets to identify global regions that yield stable biomarkers, while the local dataset learns its own specific regions to further enhance the performance of ADHD classification. 
Main results. By employing this module, our experiments achieve an average accuracy of 96.7% on diverse datasets. Importantly, the discriminative gradient components primarily originate from the global regions, providing evidence for the significance of these regions. We further identify regions with the high appearance frequencies as biomarkers. All the used global regions and one local region are recognized, primarily belonging to the limbic system. 
Significance. These biomarkers align with existing research on impaired working memory and abnormal emotional reactivity in children with ADHD. Thus, our method demonstrates its validity by providing enhanced biological explanations derived from ADHD mechanisms.

Heterogeneous treatment effect of dose-dense paclitaxel plus carboplatin therapy for advanced ovarian cancer.

A Japanese clinical trial (JGOG3016) showed that dose-dense weekly paclitaxel in combination with carboplatin extensively prolonged overall survival (OS) in patients with advanced ovarian cancer. However, in other clinical trials, dose-dense paclitaxel regimens were not superior to triweekly paclitaxel regimens. In this study, causal tree analysis was applied to explore subpopulations with different treatment effects of dose-dense paclitaxel in a data-driven approach. The 587 participants with stage II-IV ovarian cancer in the JGOG3016 trial were used for model development. The primary endpoint was treatment effect in terms of 3-year OS in patients receiving dose-dense vs. conventional paclitaxel therapies. In patients <50 years, the 3-year OS was similar in both groups; however, it was higher in the dose-dense group in patients ≥50 years. Dose-dense paclitaxel showed strong positive treatment effects in patients ≥50 years with stage II/III disease, BMI <23 kg/m2, non-CC/MC, and residual tumor ≥1 cm. In contrast, although there was no significant difference in OS; the 3-year OS rate was 23% lower in dose-dense paclitaxel than conventional paclitaxel in patients ≥60 years with stage IV cancer. Patients in this group had a particularly lower performance status than other groups. Our causal tree analysis suggested that poor prognosis groups represented by residual tumor tissue ≥1 cm benefit from dose-dense paclitaxel, whereas elderly patients with advanced disease and low-performance status are negatively impacted by dose-dense paclitaxel. These subpopulations will be of interest to future validation studies. Personalized treatments based on clinical features are expected to improve advanced ovarian cancer prognosis.

Global Inequalities in Access and Success in Higher Education

Despite its pivotal importance, the fundamental right to higher education remains far from universal, with inequalities in access to and success in higher education observed in almost all countries around the world. This article highlights some of the key inequalities that impede equitable access and success in higher education and outlines the diverse policy initiatives implemented by governments worldwide in their attempt to tackle this global challenge. It underscores the importance of elevating this issue as a global policy priority through collaborative, data-driven, innovative and comprehensive approaches.